For research use only. Not for therapeutic Use.
N-<wbr></wbr>Acylated ethanolamines (NAE) are naturally-<wbr></wbr>occurring lipids that have diverse bioactivities. For example, arachidonoyl ethanolamide (AEA) is an endogenous neurotransmitter that evokes cellular responses by activating the cannabinoid receptors, central cannabinoid (CB<sub>1</sub>) and peripheral cannabinoid (CB<sub>2</sub>). The different types of NAE are derived from glycerophospho-<wbr></wbr>linked precursors by the activity of glycerophosphodiesterase 1 (GDE1). Glycerophospho-<wbr></wbr>N-<wbr></wbr>palmitoyl ethanolamine (GP-<wbr></wbr>NPEA) is the metabolic precursor of palmitoyl ethanolamide (PEA). PEA is an endogenous cannabinoid found in brain, liver, and other mammalian tissues, that has potent anti-<wbr></wbr>inflammatory activity <em>in vivo</em>. PEA has low affinity for peripheral cannabinoid (CB<sub>2</sub>) and no appreciable affinity for central cannabinoid (CB<sub>1</sub>), suggesting that its efficacy is through a different receptor.
| Catalog Number | M132538 |
| CAS Number | 100575-09-5 |
| Synonyms | GP-NAE;GP-NPEA |
| Molecular Formula | C21H44NO7P |
| Purity | ≥95% |
| Storage | -20°C |
| IUPAC Name | 2,3-dihydroxypropyl 2-(hexadecanoylamino)ethyl hydrogen phosphate |
| InChI | InChI=1S/C21H44NO7P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-21(25)22-16-17-28-30(26,27)29-19-20(24)18-23/h20,23-24H,2-19H2,1H3,(H,22,25)(H,26,27) |
| InChIKey | FIXMIXZULLAMCB-UHFFFAOYSA-N |
| SMILES | CCCCCCCCCCCCCCCC(=O)NCCOP(=O)(O)OCC(CO)O |
