GPNA hydrochloride

• CAT Number: I015626
• CAS Number: 67953-08-6
• Molecular Formula: C₁₁H₁₄ClN₃O₅
• Molecular Weight: 303.7
• Purity: ≥95%
• Target: Apoptosis
• Storage: 2-8°C
• IUPAC Name: (2S)-2-amino-5-(4-nitroanilino)-5-oxopentanoic acid;hydrochloride
• InChI: InChI=1S/C11H13N3O5.ClH/c12-9(11(16)17)5-6-10(15)13-7-1-3-8(4-2-7)14(18)19;/h1-4,9H,5-6,12H2,(H,13,15)(H,16,17);1H/t9-;/m0./s1
• InChIKey: OJEVFSFTVARWQX-FVGYRXGTSA-N
• SMILES: C1=CC(=CC=C1NC(=O)CCC(C(=O)O)N)[N+](=O)[O-].Cl

GPNA hydrochloride（Cat No.:I015626） is a widely recognized substrate of the enzyme γ-glutamyltransferase (GGT). It is a specific inhibitor of the glutamine (Gln) transporter ASCT2 and also inhibits Na+-dependent carriers such as SNAT family (SNAT1/2/4/5) and the Na+-independent leucine transporters LAT1/2. GPNA hydrochloride has been found to reversibly induce apoptosis in A549 cells, a human lung cancer cell line.

Reference

[1]. Corti A, et al. γ-Glutamyltransferase enzyme activity of cancer cells modulates L-γ-glutamyl-p-nitroanilide (GPNA) cytotoxicity. Sci Rep. 2019 Jan 29;9(1):891.