GPR109 receptor agonist-1

• CAT Number: I007240
• CAS Number: 306935-41-1
• Molecular Formula: C10H11N3O2
• Molecular Weight: 205.21
• Purity: ≥95%
• Synonyms: 1-propan-2-ylbenzotriazole-5-carboxylic acid
• InChI: InChI=1S/C10H11N3O2/c1-6(2)13-9-4-3-7(10(14)15)5-8(9)11-12-13/h3-6H,1-2H3,(H,14,15)
• InChIKey: RUTVRAJKELSHCC-UHFFFAOYSA-N
• SMILES: CC(C)N1C2=C(C=C(C=C2)C(=O)O)N=N1

GPR109 receptor agonist-1 (Compound 3a) is a highly selective agonist of the human orphan G-protein-coupled receptor GPR109b, with the pEC50 of 6.4. GPR109 receptor agonist-1 can be used for the research of cardio-metabolic diseases[1].

Reference

[1]. Graeme Semple, et al. 1-Alkyl-benzotriazole-5-carboxylic acids are highly selective agonists of the human orphan G-protein-coupled receptor GPR109b. J Med Chem. 2006 Feb 23;49(4):1227-30.
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