GPR183 antagonist-2

• CAT Number: I040152
• CAS Number: 2924063-98-7
• Molecular Formula: C20H18F2N4O5
• Molecular Weight: 432.38
• Purity: ≥95%
• Synonyms: (E)-3-(2,2-difluoro-1,3-benzodioxol-5-yl)-1-[4-(2-methoxypyrimidine-5-carbonyl)piperazin-1-yl]prop-2-en-1-one
• InChI: InChI=1S/C20H18F2N4O5/c1-29-19-23-11-14(12-24-19)18(28)26-8-6-25(7-9-26)17(27)5-3-13-2-4-15-16(10-13)31-20(21,22)30-15/h2-5,10-12H,6-9H2,1H3/b5-3+
• InChIKey: VLODLHKKDGGSJO-HWKANZROSA-N
• SMILES: COC1=NC=C(C=N1)C(=O)N2CCN(CC2)C(=O)C=CC3=CC4=C(C=C3)OC(O4)(F)F

GPR183 antagonist-2 (Cat No.: I040152) is a selective small-molecule inhibitor targeting GPR183, a G protein-coupled receptor (GPCR) that regulates immune cell migration and homeostasis. By blocking GPR183, antagonist-2 disrupts the signaling pathways involved in immune responses, particularly affecting the movement and activation of B cells and dendritic cells. This can have therapeutic implications for autoimmune disorders, chronic inflammation, and certain types of cancer. Early preclinical results suggest GPR183 antagonist-2 may help modulate immune dysfunction and reduce disease progression.

Reference

[1]. Xi J, et al. Discovery of a First-in-Class GPR183 Antagonist for the Potential Treatment of Rheumatoid Arthritis. J Med Chem. 2023 Dec 14;66(23):15926-15943.
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