For research use only. Not for therapeutic Use.
GPR183 antagonist-2 (compound 32) is a selective GPR183 antagonist with good water solubility and excellent pharmacokinetic properties. GPR183 antagonist-2 significantly reduces paw and joint swelling and gene expression of pro-inflammatory cytokines (MCP-1, MMPs, and VEGF) in a collagen-induced arthritis (CIA) mouse model in a dose-dependent manner. GPR183 antagonist-2 can be used in the study of autoimmune diseases[1].
| Catalog Number | I040152 |
| CAS Number | 2924063-98-7 |
| Synonyms | (E)-3-(2,2-difluoro-1,3-benzodioxol-5-yl)-1-[4-(2-methoxypyrimidine-5-carbonyl)piperazin-1-yl]prop-2-en-1-one |
| Molecular Formula | C20H18F2N4O5 |
| Purity | ≥95% |
| InChI | InChI=1S/C20H18F2N4O5/c1-29-19-23-11-14(12-24-19)18(28)26-8-6-25(7-9-26)17(27)5-3-13-2-4-15-16(10-13)31-20(21,22)30-15/h2-5,10-12H,6-9H2,1H3/b5-3+ |
| InChIKey | VLODLHKKDGGSJO-HWKANZROSA-N |
| SMILES | COC1=NC=C(C=N1)C(=O)N2CCN(CC2)C(=O)C=CC3=CC4=C(C=C3)OC(O4)(F)F |
| Reference | [1]. Xi J, et al. Discovery of a First-in-Class GPR183 Antagonist for the Potential Treatment of Rheumatoid Arthritis. J Med Chem. 2023 Dec 14;66(23):15926-15943. |
