GPR3 agonist-2

• CAT Number: I040584
• CAS Number: 1983120-51-9
• Molecular Formula: C14H7F6IO4S
• Molecular Weight: 512.16
• Purity: ≥95%
• Synonyms: trifluoromethanesulfonate;5-(trifluoromethoxy)-8-iodoniatricyclo[7.4.0.02,7]trideca-1(13),2(7),3,5,9,11-hexaene
• InChI: InChI=1S/C13H7F3IO.CHF3O3S/c14-13(15,16)18-8-5-6-10-9-3-1-2-4-11(9)17-12(10)7-8;2-1(3,4)8(5,6)7/h1-7H;(H,5,6,7)/q+1;/p-1
• InChIKey: RAYXTZAHMQMKFW-UHFFFAOYSA-M
• SMILES: C1=CC=C2C(=C1)C3=C([I+]2)C=C(C=C3)OC(F)(F)F.C(F)(F)(F)S(=O)(=O)[O-]

GPR3 agonist-2(compound 32) is a potent full agonist of G protein-coupled receptor 3, with the IC50of 260 nM[1].

Reference

[1]. Gay EA, et al. The development of diphenyleneiodonium analogs as GPR3 agonists. Bioorg Med Chem Lett. 2023;94:129427.
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