GPR84 antagonist 8

• CAT Number: I020020
• CAS Number: 1445846-30-9
• Molecular Formula: C₂₃H₂₃N₃O₅
• Molecular Weight: 421.45
• Purity: ≥95%
• Target: GPR84
• Storage: Store at -20°C
• IUPAC Name: 2-(1,4-dioxan-2-ylmethoxy)-9-(pyridin-2-ylmethoxy)-6,7-dihydropyrimido[6,1-a]isoquinolin-4-one
• InChI: InChI=1S/C23H23N3O5/c27-23-25-22(31-15-19-14-28-9-10-29-19)12-21-20-5-4-18(11-16(20)6-8-26(21)23)30-13-17-3-1-2-7-24-17/h1-5,7,11-12,19H,6,8-10,13-15H2
• InChIKey: KSGKMLVYIUJQMZ-UHFFFAOYSA-N
• SMILES: C1CN2C(=CC(=NC2=O)OCC3COCCO3)C4=C1C=C(C=C4)OCC5=CC=CC=N5

GPR84 antagonist 8（Cat No.:I020020） is a compound that acts as a selective antagonist of the GPR84 receptor. GPR84 is a G protein-coupled receptor involved in various physiological processes, including immune response and inflammation. By specifically targeting and blocking GPR84, antagonist 8 can modulate the signaling pathway associated with this receptor. This selective antagonism may have potential therapeutic applications in conditions where GPR84 activation is implicated, such as inflammatory diseases.

Reference

[1]. Recio C, et al. Activation of the Immune-Metabolic Receptor GPR84 Enhances Inflammation and Phagocytosis in Macrophages. Front Immunol. 2018 Jun 20;9:1419.