GR 218,231

• CAT Number: I007030
• CAS Number: 175442-95-2
• Molecular Formula: C24H33NO3S
• Molecular Weight: 415.59
• Purity: ≥95%
• Synonyms: GR 218,231; GR218,231; GR-218,231.;(2R)-6-[(4-methoxyphenyl)sulfonylmethyl]-N,N-dipropyl-1,2,3,4-tetrahydronaphthalen-2-amine
• Target: D3 Receptor antagonist
• Solubility: Soluble in DMSO
• Storage: 0 - 4°C for short term or -20 °C for long term
• IUPAC Name: (2R)-6-[(4-methoxyphenyl)sulfonylmethyl]-N,N-dipropyl-1,2,3,4-tetrahydronaphthalen-2-amine
• InChI: InChI=1S/C24H33NO3S/c1-4-14-25(15-5-2)22-9-8-20-16-19(6-7-21(20)17-22)18-29(26,27)24-12-10-23(28-3)11-13-24/h6-7,10-13,16,22H,4-5,8-9,14-15,17-18H2,1-3H3/t22-/m1/s1
• InChIKey: HUXFXXWYIRBVJR-JOCHJYFZSA-N
• SMILES: CCCN(CCC)[C@@H]1CCC2=C(C1)C=CC(=C2)CS(=O)(=O)C3=CC=C(C=C3)OC

GR 218,231（Cat No.:I007030）is a selective antagonist of the dopamine D4 receptor, a subtype of the dopamine receptor involved in various neurological and psychiatric functions. By blocking D4 receptor activity, GR 218,231 has been studied for its potential to treat conditions like schizophrenia, bipolar disorder, and other dopamine-related disorders. It is also being investigated for its effects on cognition and behavior, as the D4 receptor plays a role in mood regulation and attention. Although promising in preclinical studies, further research and clinical trials are necessary to fully understand its therapeutic potential and safety.

Reference

1:de Vries EF, Kortekaas R, van Waarde A, Dijkstra D, Elsinga PH, Vaalburg W. Synthesis and evaluation of dopamine D3 receptor antagonist 11C-GR218231 as PET tracer for P-glycoprotein. J Nucl Med. 2005 Aug;46(8):1384-92. PubMed PMID: 16085598.