For research use only. Not for therapeutic Use.
GR 55562 (dihydrochloride) is a selective 5-HT1B receptor antagonist. GR 55562 can be used for the research of nerve disease[1].
GR 55562 (0.1-10 μg/side) into accumbens subregions did not evoke cocaine-lever responding[1].
GR 55562 (0.1-10 μg/side) in the accumbens shell or core failed to modulate the discriminative stimulus effects of cocaine (5 mg/kg)[1].
GR 55562 (1 μg/side) significantly attenuated the enhancement of cocaine discrimination[1].
| Catalog Number | I007031 |
| CAS Number | 159533-25-2 |
| Synonyms | 3-[3-(dimethylamino)propyl]-4-hydroxy-N-(4-pyridin-4-ylphenyl)benzamide;dihydrochloride |
| Molecular Formula | C23H27Cl2N3O2 |
| Purity | ≥95% |
| InChI | InChI=1S/C23H25N3O2.2ClH/c1-26(2)15-3-4-19-16-20(7-10-22(19)27)23(28)25-21-8-5-17(6-9-21)18-11-13-24-14-12-18;;/h5-14,16,27H,3-4,15H2,1-2H3,(H,25,28);2*1H |
| InChIKey | KBKWJHYQFQONBJ-UHFFFAOYSA-N |
| SMILES | CN(C)CCCC1=C(C=CC(=C1)C(=O)NC2=CC=C(C=C2)C3=CC=NC=C3)O.Cl.Cl |
| Reference | [1]. Filip M, et al. Effects of serotonin (5-HT)(1B) receptor ligands, microinjected into accumbens subregions, on cocaine discrimination in rats. Naunyn Schmiedebergs Arch Pharmacol. 2002;366(3):226-234. |
