GR 64349

• CAT Number: R036433
• CAS Number: 137593-52-3
• Molecular Formula: C42H68N10O11S
• Molecular Weight: 921.11
• Purity: ≥95%
• IUPAC Name: (3S)-4-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(3R)-1-[(2S)-1-[[(2S)-1-amino-4-methylsulfanyl-1-oxobutan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]-2-oxopyrrolidin-3-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-3-[[(2S)-2,6-diaminohexanoyl]amino]-4-oxobutanoic acid
• InChI: 1S/C42H68N10O11S/c1-23(2)19-32(40(61)46-27(35(45)56)15-18-64-5)52-17-14-28(42(52)63)47-41(62)34(24(3)4)51-38(59)29(20-25-11-7-6-8-12-25)49-39(60)31(22-53)50-37(58)30(21-33(54)55)48-36(57)26(44)13-9-10-16-43/h6-8,11-12,23-24,26-32,34,53H,9-10,13-22,43-44H2,1-5H3,(H2,45,56)(H,46,61)(H,47,62)(H,48,57)(H,49,60)(H,50,58)(H,51,59)(H,54,55)/t26-,27-,28+,29-,30-,31-,32-,34-/m0/s1
• InChIKey: HVUNRXRFMQDMBO-ICQHUDCBSA-N
• SMILES: CC(C)C[C@@H](C(=O)N[C@@H](CCSC)C(=O)N)N1CC[C@H](C1=O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC2=CC=CC=C2)NC(=O)[C@H](CO)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCCCN)N

GR 64349 is a synthetic compound known for its role as a selective serotonin 5-HT3 receptor antagonist. It is primarily investigated for its potential therapeutic applications in treating gastrointestinal disorders, particularly nausea and vomiting associated with chemotherapy. By blocking the action of serotonin at 5-HT3 receptors, GR 64349 helps alleviate these symptoms, providing relief for patients. Its unique pharmacological profile and specificity make it a subject of interest in drug development, aiming to improve patient outcomes in various clinical settings.