For research use only. Not for therapeutic Use.
Granisetron is a serotonin 5-HT3 receptor antagonist,used to treat chemotherapy-induced nausea and vomiting.<br>Granisetron blocks the delayed rectifier current (IK) of feline isolated ventricular myocytes with a KD of 4.3 mM. Granisetron shows an intrinsic voltage-dependence as the block increases with depolarization. Granisetron blocks from the intracellular side at a binding site located 10% across the transmembrane electrical field. Granisetron (3 mM) prolongs the action potential duration (APD) by about 30% at 0.5 Hz in feline isolated ventricular myocytes.<br>Granisetron provides a substantial benefit against cisplatin-induced emesis in the piglet, some animals being completely protected during both the acute and the delayed phases.
| Catalog Number | A000463 |
| CAS Number | 107007-99-8 |
| Synonyms | NA |
| Molecular Formula | C18H24N4O • HCl |
| Purity | ≥95% |
| Target | Neuronal Signaling |
| Solubility | Limited solubility |
| Storage | 3 years -20C powder |
| InChIKey | QYZRTBKYBJRGJB-WQTKJZBYSA-N |
