For research use only. Not for therapeutic Use.
Griseofulvin（Cat No.:A000742）is an antifungal medication used primarily to treat dermatophytic infections such as ringworm, athlete’s foot, and jock itch. It works by binding to fungal microtubules, disrupting mitosis and inhibiting fungal cell division. Griseofulvin is particularly effective for infections involving hair, nails, and skin, as it accumulates in keratin-rich tissues, providing targeted antifungal action. Administered orally, it requires prolonged treatment to allow complete replacement of infected tissues. Griseofulvin is a well-established antifungal, offering a reliable treatment option for chronic or severe fungal infections.
| Catalog Number | A000742 |
| CAS Number | 126-07-8 |
| Synonyms | NA |
| Molecular Formula | C17H17CIO6 |
| Purity | ≥95% |
| Target | Microtubule/Tubulin |
| Solubility | >10.5mg/mL in DMSO |
| Storage | 3 years -20C powder |
| IUPAC Name | (2S,5'R)-7-chloro-3',4,6-trimethoxy-5'-methylspiro[1-benzofuran-2,4'-cyclohex-2-ene]-1',3-dione |
| InChI | InChI=1S/C17H17ClO6/c1-8-5-9(19)6-12(23-4)17(8)16(20)13-10(21-2)7-11(22-3)14(18)15(13)24-17/h6-8H,5H2,1-4H3/t8-,17+/m1/s1 |
| InChIKey | DDUHZTYCFQRHIY-RBHXEPJQSA-N |
| SMILES | C[C@@H]1CC(=O)C=C([C@]12C(=O)C3=C(O2)C(=C(C=C3OC)OC)Cl)OC |
| Reference | <p>Rice, Louis B., and Mahmoud A. Ghannoum. /Antifungal Agents: Mode of Action, Mechanisms of Resistance, and Correlation of These Mechanisms with Bacterial Resistance./ Clinical Microbiology Reviews (1999): 501-17. www.ncbi.gov. Oct. 1999. Web. 22 Aug. 2012.</p><p>Santra, Manas K., and Leslie Wilson. /Kinetic Suppression of Microtubule Dynamic Instability by Griseofulvin: Implications for Its Possible Use in the Treatment of Cancer./ PNAS pag. Pnas.org. 19 May 2005. Web. 22 Aug. 2012.</p></span></p> |
