For research use only. Not for therapeutic Use.
GRL-0496 is a potent chloropyridyl ester-derived SARS-CoV 3CLpro inhibitor, with an IC50 of 30 nM in both enzyme inhibitory and antiviral assays. GRL-0496 shows SARS-CoV antiviral activity, with an EC50 of 6.9 μM[1].
GRL-0496 shows the best SARS-CoV antiviral activity, with an EC EC50 of 6.9 μM[1].
| Catalog Number | I044651 |
| CAS Number | 1087243-14-8 |
| Synonyms | (5-chloropyridin-3-yl) 1H-indole-4-carboxylate |
| Molecular Formula | C14H9ClN2O2 |
| Purity | ≥95% |
| InChI | InChI=1S/C14H9ClN2O2/c15-9-6-10(8-16-7-9)19-14(18)12-2-1-3-13-11(12)4-5-17-13/h1-8,17H |
| InChIKey | BOSZJNSICHFHMA-UHFFFAOYSA-N |
| SMILES | C1=CC(=C2C=CNC2=C1)C(=O)OC3=CC(=CN=C3)Cl |
| Reference | [1]. Ghosh AK, et, al. Design, synthesis and antiviral efficacy of a series of potent chloropyridyl ester-derived SARS-CoV 3CLpro inhibitors. Bioorg Med Chem Lett. 2008 Oct 15;18(20):5684-8. |
