GRL-1720 TFA

• CAT Number: I040299
• Molecular Formula: C16H12ClF3N2O4
• Molecular Weight: 388.73
• Purity: ≥95%
• Synonyms: (5-chloropyridin-3-yl) 2,3-dihydro-1H-indole-4-carboxylate;2,2,2-trifluoroacetic acid
• InChI: InChI=1S/C14H11ClN2O2.C2HF3O2/c15-9-6-10(8-16-7-9)19-14(18)12-2-1-3-13-11(12)4-5-17-13;3-2(4,5)1(6)7/h1-3,6-8,17H,4-5H2;(H,6,7)
• InChIKey: ISYUUWQBWRIXPZ-UHFFFAOYSA-N
• SMILES: C1CNC2=CC=CC(=C21)C(=O)OC3=CC(=CN=C3)Cl.C(=O)(C(F)(F)F)O

GRL-1720 TFA is a potent inhibitor of SARS-CoV-2 Mpro with an EC50 value of 15 μM. GRL-1720 TFA shows anti-SARS-CoV2 activity[1].

Reference

[1]. Hattori SI, et al. A small molecule compound with an indole moiety inhibits the main protease of SARS-CoV-2 and blocks virus replication. Nat Commun. 2021 Jan 28;12(1):668.
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