For research use only. Not for therapeutic Use.
GS-441524（Cat No.:I017264）is a nucleoside analog and the parent compound of Remdesivir, developed by Gilead Sciences. It is an antiviral agent that inhibits RNA-dependent RNA polymerase, preventing viral replication. GS-441524 has shown efficacy against a range of RNA viruses, including coronaviruses, flaviviruses, and retroviruses. It gained attention for its potential use in treating COVID-19, but it has also been studied in veterinary medicine, particularly for treating feline infectious peritonitis (FIP) in cats. GS-441524 has demonstrated promise in preclinical and clinical trials, showing potential for broader antiviral applications.
| Catalog Number | I017264 |
| CAS Number | 1191237-69-0 |
| Molecular Formula | C₁₂H₁₃N₅O₄ |
| Purity | ≥95% |
| Target | Anti-infection |
| IUPAC Name | (2R,3R,4S,5R)-2-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-3,4-dihydroxy-5-(hydroxymethyl)oxolane-2-carbonitrile |
| InChI | InChI=1S/C12H13N5O4/c13-4-12(10(20)9(19)7(3-18)21-12)8-2-1-6-11(14)15-5-16-17(6)8/h1-2,5,7,9-10,18-20H,3H2,(H2,14,15,16)/t7-,9-,10-,12+/m1/s1 |
| InChIKey | BRDWIEOJOWJCLU-LTGWCKQJSA-N |
| SMILES | C1=C2C(=NC=NN2C(=C1)[C@]3([C@@H]([C@@H]([C@H](O3)CO)O)O)C#N)N |
| Reference | [1]. Murphy BG, et al. The nucleoside analog GS-441524 strongly inhibits feline infectious peritonitis (FIP) virus in tissue culture and experimental cat infection studies. Vet Microbiol. 2018 Jun;219:226-233.<br>[2]. Katherine Yang, et al. What Do We Know About Remdesivir Drug Interactions? Clin Transl Sci. 2020 May 13;10.1111/cts.12815.<br>[3]. Victoria C. Yan, et al. Advantages of the Parent Nucleoside GS-441524 over Remdesivir for Covid-19 Treatment. ACS Med. Chem. Lett. 2020. |
