GS-443902 trisodium

• CAT Number: I015531
• CAS Number: 1355050-21-3
• Molecular Formula: C₁₂H₁₃N₅Na₃O₁₃P₃
• Molecular Weight: 597.15
• Purity: ≥95%
• Target: Anti-infection
• IUPAC Name: tetrasodium;[[[(2R,3S,4R,5R)-5-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-5-cyano-3,4-dihydroxyoxolan-2-yl]methoxy-oxidophosphoryl]oxy-oxidophosphoryl] phosphate
• InChI: InChI=1S/C12H16N5O13P3.4Na/c13-4-12(8-2-1-6-11(14)15-5-16-17(6)8)10(19)9(18)7(28-12)3-27-32(23,24)30-33(25,26)29-31(20,21)22;;;;/h1-2,5,7,9-10,18-19H,3H2,(H,23,24)(H,25,26)(H2,14,15,16)(H2,20,21,22);;;;/q;4*+1/p-4/t7-,9-,10-,12+;;;;/m1..../s1
• InChIKey: GONGCFUOBMNVIT-ZTYDICHKSA-J
• SMILES: C1=C2C(=NC=NN2C(=C1)[C@]3([C@@H]([C@@H]([C@H](O3)COP(=O)([O-])OP(=O)([O-])OP(=O)([O-])[O-])O)O)C#N)N.[Na+].[Na+].[Na+].[Na+]

GS-443902 trisodium（Cat No.:I015531）is the active triphosphate metabolite of remdesivir, a nucleotide analog antiviral agent used in the treatment of RNA virus infections, including SARS-CoV-2. GS-443902 inhibits viral RNA-dependent RNA polymerase (RdRp) by incorporating into the growing viral RNA chain, causing premature termination and halting replication. Its broad-spectrum antiviral activity and high potency against coronaviruses and other RNA viruses make it a critical compound in virology research. GS-443902 trisodium is instrumental in understanding viral replication mechanisms and advancing the development of nucleoside analog-based antiviral therapies.

Reference

[1]. Siegel D, et al. Discovery and Synthesis of a Phosphoramidate Prodrug of a Pyrrolo[2,1-f][triazin-4-amino] Adenine C-Nucleoside (GS-5734) for the Treatment of Ebola and Emerging Viruses. Med Chem. 2017 Mar 9;60(5):1648-1661.[2]. Warren TK, et al. Therapeutic efficacy of the small molecule GS-5734 against Ebola virus in rhesus monkeys. Nature. 2016 Mar 17;531(7594):381-5.[3]. Cho A, et al. Synthesis and antiviral activity of a series of 1′-substituted 4-aza-7,9-dideazaadenosine C-nucleosides. Bioorg Med Chem Lett. 2012 Apr 15;22(8):2705-7.