For research use only. Not for therapeutic Use.
GS-704277(CAT: I013606) is a potent antiviral compound that has been investigated for its activity against a range of viral infections. It is a prodrug of Clevudine, designed to enhance the pharmacokinetic properties and antiviral efficacy of its active metabolite. GS-704277 works by inhibiting viral DNA polymerase, thereby blocking viral replication. Its primary application has been in the treatment of hepatitis B virus (HBV) infections, where it has shown promising results in reducing viral load and improving liver function in clinical studies. Due to its prodrug nature, GS-704277 offers improved bioavailability and a more favorable dosing regimen, making it a candidate for further development in antiviral therapies.
| Catalog Number | I013606 |
| CAS Number | 1911579-04-8 |
| Molecular Formula | C₁₅H₁₉N₆O₈P |
| Purity | ≥95% |
| Target | Drug Metabolite |
| IUPAC Name | (2S)-2-[[[(2R,3S,4R,5R)-5-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-5-cyano-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]amino]propanoic acid |
| InChI | InChI=1S/C15H19N6O8P/c1-7(14(24)25)20-30(26,27)28-4-9-11(22)12(23)15(5-16,29-9)10-3-2-8-13(17)18-6-19-21(8)10/h2-3,6-7,9,11-12,22-23H,4H2,1H3,(H,24,25)(H2,17,18,19)(H2,20,26,27)/t7-,9+,11+,12+,15-/m0/s1 |
| InChIKey | IYHPTSNEWCZBDF-NIFWRESRSA-N |
| SMILES | C[C@@H](C(=O)O)NP(=O)(O)OC[C@@H]1[C@H]([C@H]([C@](O1)(C#N)C2=CC=C3N2N=CN=C3N)O)O |
| Reference | [1]. Eastman RT, et al. Remdesivir: A Review of Its Discovery and Development Leading to Emergency Use Authorization for Treatment of COVID-19 [published correction appears in ACS Cent Sci. 2020 Jun 24;6(6):1009]. ACS Cent Sci. 2020;6(5):672-683.<br>[2]. Wang M, et al. Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro. Cell Res. 2020 Mar;30(3):269-271. |
