For research use only. Not for therapeutic Use.
GSA-10 is a potent smooth (Smo) receptor agonist. GSA-10 is a potent osteogenic molecule. GSA-10 can mediate Hedgehog (Hh) signaling. GSA-10 can be used in regenerative medicine for cancer disease and in the study of fat development[1][2][3].
GSA-10 (3 μM; 6 days) can induce cell differentiation into osteoblasts in pluripotent stromal cells C3H10T1/2 with an EC50 of 1.2 μM[1][2].
GSA-10 (10 μM; 24 h) inhibits fat formation in 3T3-L1 preadipocytes by activating the Smo-Lkb1-Ampk pathway[3].
| Catalog Number | R062081 |
| CAS Number | 300833-95-8 |
| Synonyms | propyl 4-[(1-hexyl-4-hydroxy-2-oxoquinoline-3-carbonyl)amino]benzoate |
| Molecular Formula | C26H30N2O5 |
| Purity | ≥95% |
| InChI | InChI=1S/C26H30N2O5/c1-3-5-6-9-16-28-21-11-8-7-10-20(21)23(29)22(25(28)31)24(30)27-19-14-12-18(13-15-19)26(32)33-17-4-2/h7-8,10-15,29H,3-6,9,16-17H2,1-2H3,(H,27,30) |
| InChIKey | MDLUYYGRCGDKGL-UHFFFAOYSA-N |
| SMILES | CCCCCCN1C2=CC=CC=C2C(=C(C1=O)C(=O)NC3=CC=C(C=C3)C(=O)OCCC)O |
| Reference | [1]. Gorojankina T, et al. Discovery, molecular and pharmacological characterization of GSA-10, a novel small-molecule positive modulator of Smoothened. Mol Pharmacol. 2013 May;83(5):1020-9. [2]. Manetti F, et al. Design, synthesis and biological characterization of a new class of osteogenic (1H)-quinolone derivatives. Eur J Med Chem. 2016 Oct 4;121:747-757. [3]. Fleury A, et al. Hedgehog associated to microparticles inhibits adipocyte differentiation via a non-canonical pathway. Sci Rep. 2016 Mar 24;6:23479. doi: 10.1038/srep23479. PMID: 27010359; PMCID: PMC4806302. |
