For research use only. Not for therapeutic Use.
GSK-1482160 is an orally available negative allosteric modulator of the P2X7 receptor. P2X7 receptors are involved in the production of pro-inflammatory cytokines, such as Il-1β, by central and peripheral immune cells. GSK-1482160 has the potential for the research of inflammation diseases[1].
| Catalog Number | I043962 |
| CAS Number | 1001389-72-5 |
| Synonyms | (2S)-N-[[2-chloro-3-(trifluoromethyl)phenyl]methyl]-1-methyl-5-oxopyrrolidine-2-carboxamide |
| Molecular Formula | C14H14ClF3N2O2 |
| Purity | ≥95% |
| InChI | InChI=1S/C14H14ClF3N2O2/c1-20-10(5-6-11(20)21)13(22)19-7-8-3-2-4-9(12(8)15)14(16,17)18/h2-4,10H,5-7H2,1H3,(H,19,22)/t10-/m0/s1 |
| InChIKey | BJEMSIVBBUBXMZ-JTQLQIEISA-N |
| SMILES | CN1C(CCC1=O)C(=O)NCC2=C(C(=CC=C2)C(F)(F)F)Cl |
| Reference | [1]. Ali Z, et al. Pharmacokinetic and pharmacodynamic profiling of a P2X7 receptor allosteric modulator GSK1482160 in healthy human subjects. Br J Clin Pharmacol. 2013;75(1):197-207. doi:10.1111/j.1365-2125.2012.04320.x |
