For research use only. Not for therapeutic Use.
GSK-1520489A is a PKMYT1 (active protein kinase) inhibitor (IC50=115 nM, Ki=10.94 nM)[1].
GSK-1520489A (4 µM, 24 h) treatment shows inhibition of phosphorylation of Tyr15 in Cdk1[1].
| Catalog Number | I043387 |
| CAS Number | 1042433-41-9 |
| Synonyms | N-methyl-2-[[5-methyl-2-[3-(methylsulfonylmethyl)anilino]pyrimidin-4-yl]amino]benzamide |
| Molecular Formula | C21H23N5O3S |
| Purity | ≥95% |
| InChI | InChI=1S/C21H23N5O3S/c1-14-12-23-21(24-16-8-6-7-15(11-16)13-30(3,28)29)26-19(14)25-18-10-5-4-9-17(18)20(27)22-2/h4-12H,13H2,1-3H3,(H,22,27)(H2,23,24,25,26) |
| InChIKey | AKHLCKMEVWGDGL-UHFFFAOYSA-N |
| SMILES | CC1=CN=C(N=C1NC2=CC=CC=C2C(=O)NC)NC3=CC=CC(=C3)CS(=O)(=O)C |
| Reference | [1]. Charlott Platzer, et al. Identification of PKMYT1 inhibitors by screening the GSK published protein kinase inhibitor set I and II. Bioorg Med Chem. 2018 Aug 7;26(14):4014-4024. |
