For research use only. Not for therapeutic Use.
GSK-1520489A（Cat No.:I043387）is an investigational small molecule inhibitor targeting the Bruton’s tyrosine kinase (BTK), an enzyme that plays a key role in B-cell receptor signaling, which is involved in immune cell activation and the progression of certain cancers. This compound is being developed by GlaxoSmithKline for the treatment of hematologic malignancies, including chronic lymphocytic leukemia (CLL) and mantle cell lymphoma (MCL). By inhibiting BTK, GSK-1520489A aims to block the survival signals of malignant B-cells, potentially offering a new approach for patients with B-cell-driven cancers. It is still undergoing clinical trials for efficacy and safety.
| CAS Number | 1042433-41-9 |
| Synonyms | N-methyl-2-[[5-methyl-2-[3-(methylsulfonylmethyl)anilino]pyrimidin-4-yl]amino]benzamide |
| Molecular Formula | C21H23N5O3S |
| Purity | ≥95% |
| IUPAC Name | N-methyl-2-[[5-methyl-2-[3-(methylsulfonylmethyl)anilino]pyrimidin-4-yl]amino]benzamide |
| InChI | InChI=1S/C21H23N5O3S/c1-14-12-23-21(24-16-8-6-7-15(11-16)13-30(3,28)29)26-19(14)25-18-10-5-4-9-17(18)20(27)22-2/h4-12H,13H2,1-3H3,(H,22,27)(H2,23,24,25,26) |
| InChIKey | AKHLCKMEVWGDGL-UHFFFAOYSA-N |
| SMILES | CC1=CN=C(N=C1NC2=CC=CC=C2C(=O)NC)NC3=CC=CC(=C3)CS(=O)(=O)C |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
