For research use only. Not for therapeutic Use.
GSK-239512 is a novel histamine H(3) receptor antagonist. GSK-239512 was developed for the treatment of cognitive dysfunction in neurodegenerative disorders with mild to moderate Alzheimer/’s disease.
| Catalog Number | I007088 |
| CAS Number | 720691-69-0 |
| Synonyms | GSK-239512; GSK239512; GSK 239512;;2-Pyrrolidinone, 1-(6-((3-cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)oxy)-3-pyridinyl)- |
| Molecular Formula | C23H27N3O2 |
| Purity | ≥95% |
| Target | Neuronal Signaling |
| Solubility | Soluble in DMSO |
| Storage | 0 - 4°C for short term or -20 °C for long term |
| IUPAC Name | 1-[6-[(3-cyclobutyl-1,2,4,5-tetrahydro-3-benzazepin-7-yl)oxy]pyridin-3-yl]pyrrolidin-2-one |
| InChI | InChI=1S/C23H27N3O2/c27-23-5-2-12-26(23)20-7-9-22(24-16-20)28-21-8-6-17-10-13-25(19-3-1-4-19)14-11-18(17)15-21/h6-9,15-16,19H,1-5,10-14H2 |
| InChIKey | YFRBKEVUUCQYOW-UHFFFAOYSA-N |
| SMILES | C1CC(C1)N2CCC3=C(CC2)C=C(C=C3)OC4=NC=C(C=C4)N5CCCC5=O |
| Reference | </br>1: Kubo M, Kishi T, Matsunaga S, Iwata N. Histamine H3 Receptor Antagonists for Alzheimer/’s Disease: A Systematic Review and Meta-Analysis of Randomized Placebo-Controlled Trials. J Alzheimers Dis. 2015;48(3):667-71. doi: 10.3233/JAD-150393. PubMed PMID: 26402104. |
