For research use only. Not for therapeutic Use.
GSK-3β inhibitor 2 (CAT: I016942) is a promising compound with potent inhibitory activity against glycogen synthase kinase-3 beta (GSK-3β). This inhibitor displays a high level of selectivity and oral bioavailability, making it a valuable candidate for therapeutic applications. Its remarkable inhibitory potency, with an IC50 of 1.1 nM, suggests its potential to modulate GSK-3β activity effectively. Moreover, its ability to penetrate the blood-brain barrier enhances its suitability for targeting central nervous system disorders, such as Alzheimer’s disease. GSK-3β is a key enzyme involved in various signaling pathways, and its dysregulation has been linked to neurodegenerative conditions.
| Catalog Number | I016942 |
| CAS Number | 1702428-31-6 |
| Molecular Formula | C₁₄H₁₄N₄O₃S |
| Purity | ≥95% |
| Reference | [1]. Sivaprakasam P, et al. Discovery of new acylaminopyridines as GSK-3 inhibitors by a structure guided in-depth exploration of chemical space around a pyrrolopyridinone core. Bioorg Med Chem Lett. 2015 May 1;25(9):1856-63. |
