For research use only. Not for therapeutic Use.
GSK-3 inhibitor 1 (compound core 3) is a GSK-3 inhibitor that induces stem/progenitor cell self-renewal (e.g. induces stem/progenitor cell proliferation while maintaining the ability to differentiate into tissue cells in the progeny)[1][2].
GSK-3 inhibitor 1 can be used to induce, promote or enhance the growth, proliferation or regeneration of inner ear tissues such as inner ear supporting cells or inner ear hair cells[2].
| Catalog Number | I004273 |
| CAS Number | 603272-51-1 |
| Synonyms | 3-(6-fluoro-1,10-diazatricyclo[6.4.1.04,13]trideca-2,4,6,8(13)-tetraen-3-yl)-4-imidazo[1,2-a]pyridin-3-ylpyrrole-2,5-dione;hydrochloride |
| Molecular Formula | C22H17ClFN5O2 |
| Purity | ≥95% |
| InChI | InChI=1S/C22H16FN5O2.ClH/c23-13-7-12-9-24-4-6-27-11-15(14(8-13)20(12)27)18-19(22(30)26-21(18)29)16-10-25-17-3-1-2-5-28(16)17;/h1-3,5,7-8,10-11,24H,4,6,9H2,(H,26,29,30);1H |
| InChIKey | CXXAOCQHGIGIBJ-UHFFFAOYSA-N |
| SMILES | C1CN2C=C(C3=CC(=CC(=C32)CN1)F)C4=C(C(=O)NC4=O)C5=CN=C6N5C=CC=C6.Cl |
| Reference | [1]. SOLUBILIZED COMPOSITIONS FOR CONTROLLED PROLIFERATION OF STEM CELLS / GENERATING INNER EAR HAIR CELLS USING GSK3 INHIBITORS: III. 20170252449 A1 [2]. Christopher Loose, et al. 1h-pyrrole-2,5-dione compounds and methods of using them to induce self-renewal of stem/progenitor supporting cells. Patent WO2018125746A1. |
