For research use only. Not for therapeutic Use.
GSK-3 Inhibitor XIII is a potent and ATP-competitive GSK-3 inhibitor with a Ki of 24 nM[1][1][2].
| Catalog Number | I043940 |
| CAS Number | 404828-14-4 |
| Synonyms | N-(5-methyl-1H-pyrazol-3-yl)-2-phenyl-5,6,7,8-tetrahydroquinazolin-4-amine |
| Molecular Formula | C18H15N5 |
| Purity | ≥95% |
| InChI | InChI=1S/C18H19N5/c1-12-11-16(23-22-12)20-18-14-9-5-6-10-15(14)19-17(21-18)13-7-3-2-4-8-13/h2-4,7-8,11H,5-6,9-10H2,1H3,(H2,19,20,21,22,23) |
| InChIKey | FAWIBADRALTDOY-UHFFFAOYSA-N |
| SMILES | CC1=CC(=NN1)NC2=NC(=NC3=C2CCCC3)C4=CC=CC=C4 |
| Reference | [1]. Albert C Pierce, et al. CH…O and CH…N hydrogen bonds in ligand design: a novel quinazolin-4-ylthiazol-2-ylamine protein kinase inhibitor. J Med Chem. 2005 Feb 24;48(4):1278-81. [2]. Eduardo Cruz Moraes, et al. Kinase inhibitor profile for human nek1, nek6, and nek7 and analysis of the structural basis for inhibitor specificity. Molecules. 2015 Jan 13;20(1):1176-91. |
