For research use only. Not for therapeutic Use.
GSK4716 is a selective agonist at estrogen-related receptors ERRβ and ERRγ. GSK4716 displays selectivity over ERRα and the classical estrogen receptors.
| Catalog Number | R025790 |
| CAS Number | 101574-65-6 |
| Synonyms | 4-Hydroxybenzoic Acid [[4-(1-Methylethyl)phenyl]methylene]hydrazide; p-Hydroxybenzoic Acid p-Isopropylbenzylidenehydrazide |
| Molecular Formula | C17H18N2O2 |
| Purity | ≥95% |
| Target | Estrogen Receptor/ERR |
| Solubility | Soluble in DMSO > 10 mM |
| Storage | Store at +4C |
| InChI | InChI=1S/C17H18N2O2/c1-12(2)14-5-3-13(4-6-14)11-18-19-17(21)15-7-9-16(20)10-8-15/h3-12,20H,1-2H3,(H,19,21)/b18-11+ |
| InChIKey | IKPPIUNQWSRCOZ-WOJGMQOQSA-N |
| SMILES | OC1=CC=C(C(N/N=C/C2=CC=C(C(C)C)C=C2)=O)C=C1 |
| Reference | </br>1: Wang SC, Myers S, Dooms C, Capon R, Muscat GE. An ERRbeta/gamma agonist modulates GRalpha expression, and glucocorticoid responsive gene expression in skeletal muscle cells. Mol Cell Endocrinol. 2010 Feb 5;315(1-2):146-52. doi: 10.1016/j.mce.2009.07.012. PubMed PMID: 19631715.</br>2: Kim Y, Koh M, Kim DK, Choi HS, Park SB. Efficient discovery of selective small molecule agonists of estrogen-related receptor gamma using combinatorial approach. J Comb Chem. 2009 Sep-Oct;11(5):928-37. doi: 10.1021/cc900081j. PubMed PMID: 19746993.</br>3: Di Micco S, Renga B, Carino A, D/’Auria MV, Zampella A, Riccio R, Fiorucci S, Bifulco G. Structural insights into Estrogen Related Receptor-β modulation: 4-methylenesterols from Theonella swinhoei sponge as the first example of marine natural antagonists. Steroids. 2014 Feb;80:51-63. doi: 10.1016/j.steroids.2013.11.017. PubMed PMID: 24315836.</br></br> |
