For research use only. Not for therapeutic Use.
GSK 650394（Cat No.:I005336）is a selective inhibitor of serum- and glucocorticoid-regulated kinase 1 (SGK1), an enzyme involved in regulating ion transport, cell survival, and stress responses. By inhibiting SGK1, GSK 650394 impacts pathways related to inflammation, insulin signaling, and cellular stress, making it valuable in research on metabolic disorders, hypertension, and fibrosis. SGK1’s role in promoting cell survival also draws interest in cancer research, where its inhibition may enhance apoptotic responses in cancer cells. GSK 650394 is a crucial tool for studying SGK1’s function in physiology and pathology.
| Catalog Number | I005336 |
| CAS Number | 890842-28-1 |
| Synonyms | 2-cyclopentyl-4-(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)benzoic acid |
| Molecular Formula | C25H22N2O2 |
| Purity | ≥95% |
| Target | Anti-infection |
| Solubility | DMSO: ≥ 40.7 mg/mL |
| Storage | Store at -20C |
| IC50 | 62 nM (SGK1); 103 nM (SGK2) |
| IUPAC Name | 2-cyclopentyl-4-(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)benzoic acid |
| InChI | InChI=1S/C25H22N2O2/c28-25(29)20-11-10-18(12-21(20)17-8-4-5-9-17)23-15-27-24-22(23)13-19(14-26-24)16-6-2-1-3-7-16/h1-3,6-7,10-15,17H,4-5,8-9H2,(H,26,27)(H,28,29) |
| InChIKey | WVSBGSNVCDAMCF-UHFFFAOYSA-N |
| SMILES | C1CCC(C1)C2=C(C=CC(=C2)C3=CNC4=C3C=C(C=N4)C5=CC=CC=C5)C(=O)O |
| Reference | <p style=/line-height:25px/> |
