GSK 789472 hydrochloride

• CAT Number: I010857
• CAS Number: 1257326-24-1
• Molecular Formula: C15H22ClN3O
• Molecular Weight: 295.811
• Purity: ≥95%
• Synonyms: 4,5-Dihydro-1-phenyl-3-(2-piperidinyl)methylimidazol-2(1H)-one
• Target: Neuronal Signaling
• Solubility: Soluble to 100 mM in water and to 100 mM in DMSO
• Storage: Desiccate at RT
• IUPAC Name: 1-phenyl-3-(piperidin-2-ylmethyl)imidazolidin-2-one;hydrochloride
• InChI: InChI=1S/C15H21N3O.ClH/c19-15-17(12-13-6-4-5-9-16-13)10-11-18(15)14-7-2-1-3-8-14;/h1-3,7-8,13,16H,4-6,9-12H2;1H
• InChIKey: BYJUVPWUMBVSTK-UHFFFAOYSA-N
• SMILES: C1CCNC(C1)CN2CCN(C2=O)C3=CC=CC=C3.Cl

GSK 789472 hydrochloride(CAT: I010857) acts as a selective antagonist of the dopamine D3 receptor and a partial agonist of the dopamine D2 receptor. The compound demonstrates higher potency in antagonizing the D3 receptor (pEC50 < 5.5) compared to its partial agonist activity at the D2 receptor (pEC50 = 8.3). GSK 789472 hydrochloride exhibits selectivity against the dopamine D4 receptor in both agonist and antagonist assays. Importantly, it has the ability to cross the blood-brain barrier, suggesting its potential for central nervous system (CNS) activity.