For research use only. Not for therapeutic Use.
GSK 789472 hydrochloride(CAT: I010857) acts as a selective antagonist of the dopamine D3 receptor and a partial agonist of the dopamine D2 receptor. The compound demonstrates higher potency in antagonizing the D3 receptor (pEC50 < 5.5) compared to its partial agonist activity at the D2 receptor (pEC50 = 8.3). GSK 789472 hydrochloride exhibits selectivity against the dopamine D4 receptor in both agonist and antagonist assays. Importantly, it has the ability to cross the blood-brain barrier, suggesting its potential for central nervous system (CNS) activity.
| Catalog Number | I010857 |
| CAS Number | 1257326-24-1 |
| Synonyms | 4,5-Dihydro-1-phenyl-3-(2-piperidinyl)methylimidazol-2(1H)-one |
| Molecular Formula | C15H22ClN3O |
| Purity | ≥95% |
| Target | Neuronal Signaling |
| Solubility | Soluble to 100 mM in water and to 100 mM in DMSO |
| Storage | Desiccate at RT |
| IUPAC Name | 1-phenyl-3-(piperidin-2-ylmethyl)imidazolidin-2-one;hydrochloride |
| InChI | InChI=1S/C15H21N3O.ClH/c19-15-17(12-13-6-4-5-9-16-13)10-11-18(15)14-7-2-1-3-8-14;/h1-3,7-8,13,16H,4-6,9-12H2;1H |
| InChIKey | BYJUVPWUMBVSTK-UHFFFAOYSA-N |
| SMILES | C1CCNC(C1)CN2CCN(C2=O)C3=CC=CC=C3.Cl |
