GSK-J4 HCl

• CAT Number: I007039
• CAS Number: 1797983-09-5 (HCl)
• Molecular Formula: C24H28ClN5O2
• Molecular Weight: 453.97
• Purity: ≥95%
• Synonyms: GSK-J4 HCl; GSK J4 HCl; GSK-J4 hydrochloride.;ethyl 3-((2-(pyridin-2-yl)-6-(1,2,4,5-tetrahydro-3H-benzo[d]azepin-3-yl)pyrimidin-4-yl)amino)propanoate hydrochloride
• Target: Histone Demethylase
• Solubility: Soluble in DMSO, not in water
• Storage: 0 - 4°C for short term or -20 °C for long term
• IUPAC Name: ethyl 3-[[2-pyridin-2-yl-6-(1,2,4,5-tetrahydro-3-benzazepin-3-yl)pyrimidin-4-yl]amino]propanoate;hydrochloride
• InChI: InChI=1S/C24H27N5O2.ClH/c1-2-31-23(30)10-14-26-21-17-22(28-24(27-21)20-9-5-6-13-25-20)29-15-11-18-7-3-4-8-19(18)12-16-29;/h3-9,13,17H,2,10-12,14-16H2,1H3,(H,26,27,28);1H
• InChIKey: TYXWLTBYINKVNT-UHFFFAOYSA-N
• SMILES: O=C(OCC)CCNC1=NC(C2=NC=CC=C2)=NC(N3CCC4=CC=CC=C4CC3)=C1

GSK-J4 HCl(CAT: I007039) is a potent and selective inhibitor of the H3K27 demethylases JMJD3 (KDM6B) and UTX (KDM6A). Widely used in epigenetics research, it effectively modulates histone methylation states, influencing gene expression and chromatin dynamics. GSK-J4 HCl has demonstrated anti-inflammatory properties by suppressing pro-inflammatory cytokines, making it a valuable tool in studies of autoimmune diseases and inflammation. It also shows promise in cancer research by regulating oncogenic pathways. Its hydrochloride form enhances solubility and stability, ensuring reliable experimental outcomes. GSK-J4 HCl is essential for understanding epigenetic mechanisms and exploring therapeutic targets in diverse biological and pathological contexts.