For research use only. Not for therapeutic Use.
GSK-J5(CAT: I011002) is a potent small-molecule inhibitor with demonstrated anthelmintic activity against schistosomes and other parasitic worms. It significantly increases schistosomula mortality, impairs adult worm motility, and induces adult worm death in a dose- and time-dependent manner. GSK-J5 also disrupts egg oviposition, interfering with parasite reproduction. Originally developed as a negative control compound for epigenetic studies, GSK-J5 has shown unexpected antiparasitic effects, making it a valuable tool in parasitology research. Its unique activity profile supports further investigation into novel mechanisms for schistosomiasis treatment and highlights the potential for drug repurposing in combating helminthic infections.
| CAS Number | 1394854-51-3 |
| Synonyms | ethyl 3-[[2-pyridin-3-yl-6-(1,2,4,5-tetrahydro-3-benzazepin-3-yl)pyrimidin-4-yl]amino]propanoate |
| Molecular Formula | C24H27N5O2 |
| Purity | ≥95% |
| IUPAC Name | ethyl 3-[[2-pyridin-3-yl-6-(1,2,4,5-tetrahydro-3-benzazepin-3-yl)pyrimidin-4-yl]amino]propanoate |
| InChI | InChI=1S/C24H27N5O2/c1-2-31-23(30)9-13-26-21-16-22(28-24(27-21)20-8-5-12-25-17-20)29-14-10-18-6-3-4-7-19(18)11-15-29/h3-8,12,16-17H,2,9-11,13-15H2,1H3,(H,26,27,28) |
| InChIKey | LQPGVGSKBNXQDU-UHFFFAOYSA-N |
| SMILES | CCOC(=O)CCNC1=CC(=NC(=N1)C2=CN=CC=C2)N3CCC4=CC=CC=C4CC3 |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
