For research use only, not for therapeutic use.
GSK-LSD1 Dihydrochloride is a potent, selective and irreversible lysine specific demethylase 1 (LSD1) inhibitor with an IC50 of 16 nM.
| Catalog Number | I013239 |
| CAS Number | 2102933-95-7 |
| Molecular Formula | C₁₄H₂₂Cl₂N₂ |
| Purity | ≥95% |
| Target | Histone Demethylase Monoamine Oxidase |
| Solubility | DMSO: ≥100 mg/mL |
| IUPAC Name | N-[(1R,2S)-2-phenylcyclopropyl]piperidin-4-amine;dihydrochloride |
| InChI | InChI=1S/C14H20N2.2ClH/c1-2-4-11(5-3-1)13-10-14(13)16-12-6-8-15-9-7-12;;/h1-5,12-16H,6-10H2;2*1H/t13-,14+;;/m0../s1 |
| InChIKey | PJFZOGMSPBHPNS-WICJZZOFSA-N |
| SMILES | C1CNCCC1NC2CC2C3=CC=CC=C3.Cl.Cl |
| Reference | [1]. Purich D. The Inhibitor Index A Desk Reference on Enzyme Inhibitors, Receptor Antagonists, Drugs, Toxins, Poisons, Biologics, and Therapeutic Leads. ISBN 9781138739215<br>[2]. Wang Z, et al. Inhibition of H3K4 demethylation induces autophagy in cancer cell lines. Biochim Biophys Acta. 2017 Aug 8;1864(12):2428-2437. |
