Daprodustat

For research use only. Not for therapeutic Use.

  • CAT Number: I005696
  • CAS Number: 960539-70-2
  • Molecular Formula: C19H27N3O6
  • Molecular Weight: 393.44
  • Purity: 95%
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GSK1278863 (Cat No.:I005696) is indeed a selective and potent small molecule inhibitor of hypoxia-inducible factor (HIF) prolyl hydroxylase (PHD). By inhibiting PHD enzymes, GSK1278863 stabilizes HIF proteins and promotes their transcriptional activity, leading to increased expression of HIF target genes involved in cellular adaptation to hypoxia. This compound has shown promise in preclinical studies for its potential therapeutic applications in conditions associated with inadequate oxygen supply, such as anemia and ischemic diseases. Additionally, GSK1278863 has been investigated as a potential treatment for various types of cancer, as HIF activation is often associated with tumor progression and metastasis.


Catalog Number I005696
CAS Number 960539-70-2
Synonyms

GSK1278863; N-[(1,3-Dicyclohexylhexahydro-2,4,6-trioxo-5-pyrimidinyl)carbonyl]glycine

Molecular Formula C19H27N3O6
Purity 95%
Target HIF/HIF Prolyl-Hydroxylase
Target Protein

Q9H6Z9,Q9GZT9,Q96KS0

Solubility DMSO: < 6.8 mg/mL
Appearance Solid
Storage Dry, dark and at 2 - 8 °C for six months or -20°C for two years.
IUPAC Name 2-[(1,3-dicyclohexyl-2,4,6-trioxo-1,3-diazinane-5-carbonyl)amino]acetic acid
InChI InChI=1S/C19H27N3O6/c23-14(24)11-20-16(25)15-17(26)21(12-7-3-1-4-8-12)19(28)22(18(15)27)13-9-5-2-6-10-13/h12-13,15H,1-11H2,(H,20,25)(H,23,24)
InChIKey RUEYEZADQJCKGV-UHFFFAOYSA-N
SMILES C1CCC(CC1)N2C(=O)C(C(=O)N(C2=O)C3CCCCC3)C(=O)NCC(=O)O

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