GSK2141795 hydrochloride

• CAT Number: I000264
• CAS Number: 1047635-80-2
• Molecular Formula: C18H17Cl3F2N4O2
• Molecular Weight: 465.71
• Purity: ≥95%
• Synonyms: N-((S)-1-amino-3-(3,4-difluorophenyl)propan-2-yl)-5-chloro-4-(4-chloro-1-methyl-1H-pyrazol-5-yl)furan-2-carboxamide hydrochloride
• Target: Akt
• Solubility: 10 mM in DMSO
• Storage: Store at -20C
• IC50: 180/328/38 nM (Akt1/2/3)

GSK2141795 Hcl is a potent and selective pan-Akt inhibitor with IC50 values of 180 nM for Akt1, 328 nM for Akt2, and 38 nM for Akt3 respectively (Clinical phase 1).IC50 value: 180/328/38 nM (Akt1/2/3)Target: pan-Akt inhibitorKD values of 16 nM for Akt1, 49 nM for Akt2, and 5 nM for Akt3 (for GSK2141795), which are in line with literature data from biochemical assays that report potencies of 2 nM for Akt1, 2-13 nM for Akt2, and 3-9 nM Akt3 for GSK690693.

Reference

[1]. Pachl F, et al. Characterization of a chemical affinity probe targeting Akt kinases. J Proteome Res. 2013 Aug 2;12(8):3792-800.