GSK2193874

• CAT Number: I007081
• CAS Number: 1336960-13-4
• Molecular Formula: C37H38BrF3N4O
• Molecular Weight: 691.64
• Purity: ≥95%
• Synonyms: GSK2193874; GSK 2193874; GSK-2193874.;7-bromo-N-(1-phenylcyclopropyl)-3-[(4-piperidin-1-ylpiperidin-1-yl) methyl]-2-[3-(trifluoromethyl)phenyl]quinoline-4-carboxamide
• Target: Neuronal Signaling
• Solubility: Soluble in DMSO
• Storage: Store at +4 ℃
• IUPAC Name: 7-bromo-N-(1-phenylcyclopropyl)-3-[(4-piperidin-1-ylpiperidin-1-yl)methyl]-2-[3-(trifluoromethyl)phenyl]quinoline-4-carboxamide
• InChI: InChI=1S/C37H38BrF3N4O/c38-28-12-13-30-32(23-28)42-34(25-8-7-11-27(22-25)37(39,40)41)31(24-44-20-14-29(15-21-44)45-18-5-2-6-19-45)33(30)35(46)43-36(16-17-36)26-9-3-1-4-10-26/h1,3-4,7-13,22-23,29H,2,5-6,14-21,24H2,(H,43,46)
• InChIKey: UIVOZBSCHXCGPS-UHFFFAOYSA-N
• SMILES: C1CCN(CC1)C2CCN(CC2)CC3=C(N=C4C=C(C=CC4=C3C(=O)NC5(CC5)C6=CC=CC=C6)Br)C7=CC(=CC=C7)C(F)(F)F

GSK2193874 (CAT: I007081) is a potent antagonist of TRPV4 (transient receptor potential vanilloid 4) channels. It effectively blocks the influx of calcium induced by the TRPV4 agonist GSK634775, demonstrating IC50 values of 2, 5, and 40 nM. GSK2193874 exhibits selectivity for TRPV4 over a wide range of other human receptors, channels, and enzymes, making it a valuable tool for studying the function and pharmacology of TRPV4 channels. TRPV4 channels are involved in various physiological processes, including osmoregulation, mechanotransduction, and pain perception. The selective antagonism of TRPV4 by GSK2193874 holds promise for therapeutic applications in conditions related to TRPV4 channel dysfunction.