GSK2194069

• CAT Number: I001267
• CAS Number: 1332331-08-4
• Molecular Formula: C25H24N4O3
• Molecular Weight: 428.5
• Purity: ≥95%
• Synonyms: 4-[4-(5-benzofuranyl)phenyl]-5-[[(3S)-1-(cyclopropylcarbonyl)-3-pyrrolidinyl]methyl]-2,4-dihydro-3H-1,2,4-triazol-3-one
• Target: Fatty Acid Synthase (FASN)
• Solubility: 10 mM in DMSO
• Storage: -20°C
• InChIKey: AQTPWCUIYUOEMG-INIZCTEOSA-N

GSK2194069 is a potent and specific inhibitor of the β-ketoacyl reductase (KR) activity of hFAS with an IC50 of 7.7 ± 4.1 nM in an assay detecting released CoA.IC50 value:Target: hFAS inhibitor

Reference

[1]. Hardwicke MA, et al. A human fatty acid synthase inhibitor binds β-ketoacyl reductase in the keto-substrate site. Nat Chem Biol. 2014 Sep;10(9):774-9.