For research use only, not for therapeutic use.
GSK2256098（Cat No.:I000864）is a potent and selective inhibitor of focal adhesion kinase (FAK), a key enzyme involved in cellular adhesion, migration, and survival. By targeting FAK, GSK2256098 disrupts signaling pathways crucial for tumor growth, metastasis, and resistance to therapy, making it a valuable compound for cancer research. It has shown promise in preclinical studies for treating cancers such as mesothelioma, where FAK signaling is upregulated. GSK2256098’s role in inhibiting tumor cell adhesion and migration positions it as a potential therapeutic agent in targeted cancer therapies.
| Catalog Number | I000864 |
| CAS Number | 1224887-10-8 |
| Synonyms | 2-[[5-chloro-2-[[3-methyl-1-(1-methylethyl)-1H-pyrazol-5-yl]amino]-4-pyridinyl]amino]-N-methoxy-benzamide |
| Molecular Formula | C₂₀H₂₃ClN₆O₂ |
| Purity | ≥95% |
| Target | FAK |
| Solubility | DMSO: ≥ 30 mg/mL |
| Storage | Store at -20°C |
| IUPAC Name | 2-[[5-chloro-2-[(5-methyl-2-propan-2-ylpyrazol-3-yl)amino]pyridin-4-yl]amino]-N-methoxybenzamide |
| InChI | InChI=1S/C20H23ClN6O2/c1-12(2)27-19(9-13(3)25-27)24-18-10-17(15(21)11-22-18)23-16-8-6-5-7-14(16)20(28)26-29-4/h5-12H,1-4H3,(H,26,28)(H2,22,23,24) |
| InChIKey | BVAHPPKGOOJSPU-UHFFFAOYSA-N |
| SMILES | CC1=NN(C(=C1)NC2=NC=C(C(=C2)NC3=CC=CC=C3C(=O)NOC)Cl)C(C)C |
| Reference | </br>1:A phase I, pharmacokinetic and pharmacodynamic study of GSK2256098, a focal adhesion kinase inhibitor, in patients with advanced solid tumors. Soria JC, Gan HK, Blagden SP, Plummer R, Arkenau HT, Ranson M, Evans TR, Zalcman G, Bahleda R, Hollebecque A, Lemech C, Dean E, Brown J, Gibson D, Peddareddigari V, Murray S, Nebot N, Mazumdar J, Swartz L, Auger KR, Fleming RA, Singh R, Millward M.Ann Oncol. 2016 Dec;27(12):2268-2274. doi: 10.1093/annonc/mdw427. Epub 2016 Oct 11. PMID: 27733373 </br>2:A small molecule FAK kinase inhibitor, GSK2256098, inhibits growth and survival of pancreatic ductal adenocarcinoma cells. Zhang J, He DH, Zajac-Kaye M, Hochwald SN.Cell Cycle. 2014;13(19):3143-9. doi: 10.4161/15384101.2014.949550. PMID: 25486573 Free PMC Article |
