For research use only. Not for therapeutic Use.
GSK2578215A (Cat.No:I001116) is a selective inhibitor of the protein kinase B (Akt) pathway, a critical signaling pathway involved in cell survival and proliferation. It has shown promising results in preclinical studies, inhibiting tumor growth and inducing apoptosis in various cancer cell lines. GSK2578215A is being investigated for its therapeutic potential in cancer treatment.
| Catalog Number | I001116 |
| CAS Number | 1285515-21-0 |
| Synonyms | 2-(benzyloxy)-5-(2-fluoropyridin-4-yl)-N-(pyridin-3-yl)benzamide |
| Molecular Formula | C24H18FN3O2 |
| Purity | ≥95% |
| Target | LRRK2 |
| Solubility | 10 mM in DMSO |
| Storage | Store at RT |
| IC50 | ~10 nM(wt-LRRK2; LRRK2 G2019S) [1] |
| InChIKey | WCIGMFCFPXZRMQ-UHFFFAOYSA-N |
| Reference | </br>1:The LRRK2 inhibitor GSK2578215A induces protective autophagy in SH-SY5Y cells: involvement of Drp-1-mediated mitochondrial fission and mitochondrial-derived ROS signaling. Saez-Atienzar S, Bonet-Ponce L, Blesa JR, Romero FJ, Murphy MP, Jordan J, Galindo MF.Cell Death Dis. 2014 Aug 14;5:e1368. doi: 10.1038/cddis.2014.320. PMID: 25118928 Free PMC Article</br>2:GSK2578215A; a potent and highly selective 2-arylmethyloxy-5-substitutent-N-arylbenzamide LRRK2 kinase inhibitor. Reith AD, Bamborough P, Jandu K, Andreotti D, Mensah L, Dossang P, Choi HG, Deng X, Zhang J, Alessi DR, Gray NS.Bioorg Med Chem Lett. 2012 Sep 1;22(17):5625-9. doi: 10.1016/j.bmcl.2012.06.104. Epub 2012 Jul 7. PMID: 22863203 Free PMC Article |
