GSK2795039

• CAT Number: I001595
• CAS Number: 1415925-18-6
• Molecular Formula: C23H26N6O2S
• Molecular Weight: 450.56
• Purity: ≥95%
• Target: target:NADPH Oxidase 2
• Solubility: DMSO: ≥ 32 mg/mL
• Storage: 2-8°C
• IUPAC Name: 1-methyl-N-[3-(1-methyl-2,3-dihydroindol-6-yl)-1-propan-2-ylpyrrolo[2,3-b]pyridin-4-yl]pyrazole-3-sulfonamide
• InChI: InChI=1S/C23H26N6O2S/c1-15(2)29-14-18(17-6-5-16-8-11-27(3)20(16)13-17)22-19(7-10-24-23(22)29)26-32(30,31)21-9-12-28(4)25-21/h5-7,9-10,12-15H,8,11H2,1-4H3,(H,24,26)
• InChIKey: FMWVTCZKCXPKFW-UHFFFAOYSA-N
• SMILES: CC(C)N1C=C(C2=C(C=CN=C21)NS(=O)(=O)C3=NN(C=C3)C)C4=CC5=C(CCN5C)C=C4

GSK2795039（Cat No.:I001595）is a selective inhibitor of NADPH oxidase 2 (NOX2), a key enzyme in generating reactive oxygen species (ROS) in immune cells. By targeting NOX2, GSK2795039 reduces excessive ROS production, helping to mitigate oxidative stress linked to inflammation, cardiovascular diseases, and neurodegenerative disorders. It is particularly valuable in studying NOX2-related pathologies, including chronic inflammation and ischemic injury. Its specificity allows researchers to explore NOX2’s role in disease progression and evaluate therapeutic strategies for conditions where oxidative stress exacerbates tissue damage, advancing research in oxidative stress management and inflammation control.

Reference

[1]. Hirano K et al. Discovery of GSK2795039, a Novel Small Molecule NADPH Oxidase 2 Inhibitor. Antioxid Redox Signal. 2015 Aug 10;23(5):358-74.