GSK2807 Trifluoroacetate

• CAT Number: I019845
• CAS Number: 2245255-66-5
• Molecular Formula: C₂₁H₃₃F₃N₈O₇
• Molecular Weight: 566.53
• Purity: ≥95%
• Target: Histone Methyltransferase

GSK2807 Trifluoroacetate(CAT: I019845) is a potent and selective inhibitor of SMYD3. It acts as a competitive inhibitor of S-adenosyl methionine (SAM) and specifically targets SMYD3, a lysine methyltransferase involved in various cellular processes. By inhibiting SMYD3, GSK2807 Trifluoroacetate shows potential for therapeutic applications in cancer and other diseases where SMYD3 is implicated. Its selective inhibition of SMYD3 makes it a valuable tool for studying the biological functions of this enzyme and exploring its role in disease progression.

Reference

[1]. Van Aller GS, et al. Structure-Based Design of a Novel SMYD3 Inhibitor that Bridges the SAM-and MEKK2-Binding Pockets. Structure. 2016 May 3;24(5):774-781.[2]. Kaniskan HÜ, et al. Inhibitors of Protein Methyltransferases and Demethylases. Chem Rev. 2018 Feb 14;118(3):989-1068.