For research use only. Not for therapeutic Use.
GSK2838232（Cat No.:I001707）is a potent and selective inhibitor of HIV-1 maturation, targeting the final step in viral particle assembly. By disrupting the cleavage of Gag polyproteins into functional units, it prevents the formation of infectious viral particles. GSK2838232 exhibits strong antiviral activity against multiple HIV-1 strains, including those resistant to other therapies, making it a promising candidate in the fight against HIV. Its favorable pharmacokinetics and once-daily oral dosing support its potential for inclusion in combination antiretroviral therapies. Ongoing research explores its efficacy and safety in clinical settings.
| Catalog Number | I001707 |
| CAS Number | 1443460-91-0 |
| Synonyms | (3β)-3-(3-carboxy-3-methyl-1-oxobutoxy)-17-[(1R)-2-[[(4-chlorophenyl)methyl][2-(dimethylamino)ethyl]amino]-1-hydroxyethyl]-28-norlup-18-en-21-one |
| Molecular Formula | C48H73ClN2O6 |
| Purity | ≥95% |
| Target | HIV |
| Solubility | 10 mM in DMSO |
| Storage | -20°C |
| IUPAC Name | 4-[[(3aR,5aR,5bR,7aR,9S,11aR,11bR,13aS)-3a-[(1R)-2-[(4-chlorophenyl)methyl-[2-(dimethylamino)ethyl]amino]-1-hydroxyethyl]-5a,5b,8,8,11a-pentamethyl-2-oxo-1-propan-2-yl-4,5,6,7,7a,9,10,11,11b,12,13,13a-dodecahydro-3H-cyclopenta[a]chrysen-9-yl]oxy]-2,2-dimethyl-4-oxobutanoic acid |
| InChI | InChI=1S/C48H73ClN2O6/c1-30(2)40-34(52)26-48(37(53)29-51(25-24-50(10)11)28-31-12-14-32(49)15-13-31)23-22-46(8)33(41(40)48)16-17-36-45(7)20-19-38(57-39(54)27-43(3,4)42(55)56)44(5,6)35(45)18-21-47(36,46)9/h12-15,30,33,35-38,53H,16-29H2,1-11H3,(H,55,56)/t33-,35+,36-,37+,38+,45+,46-,47-,48+/m1/s1 |
| InChIKey | MEOWKUXNVNJAMY-PZFKGGKESA-N |
| SMILES | CC(C)C1=C2[C@H]3CC[C@@H]4[C@]5(CC[C@@H](C([C@@H]5CC[C@]4([C@@]3(CC[C@]2(CC1=O)[C@H](CN(CCN(C)C)CC6=CC=C(C=C6)Cl)O)C)C)(C)C)OC(=O)CC(C)(C)C(=O)O)C |
| Reference | <p style=/line-height:25px/> |
