For research use only. Not for therapeutic Use.
GSK369796 Dihydrochloride (Cat No.: I007108), also referred to as N-tert-butylisoquine, is an inhibitor of the hERG potassium ion channel’s repolarization process, with an IC50 of 7.5 μM. This compound is not only effective but also cost-effective, making it a valuable tool in research related to hERG channel function. Additionally, GSK369796 Dihydrochloride is recognized as a potent 4-aminoquinoline antimalarial, further showcasing its versatility in different scientific applications. For more information or inquiries about GSK369796 Dihydrochloride, please feel free to contact us, and we will respond promptly.
| Catalog Number | I007108 |
| CAS Number | 1010411-21-8 |
| Synonyms | GSK369796 Dihydrochloride; GSK 369796; GSK-369796; GSK369796; N-tert-Butyl isoquine.;2-[(tert-Butylamino)methyl]-5-[(7-chloroquinolin-4-yl)amino]phenol Dihydrochloride |
| Molecular Formula | C20H24Cl3N3O |
| Purity | ≥95% |
| Solubility | Soluble in DMSO |
| Storage | Room Temperature |
| IUPAC Name | 2-[(tert-butylamino)methyl]-5-[(7-chloroquinolin-4-yl)amino]phenol;dihydrochloride |
| InChI | InChI=1S/C20H22ClN3O.2ClH/c1-20(2,3)23-12-13-4-6-15(11-19(13)25)24-17-8-9-22-18-10-14(21)5-7-16(17)18;;/h4-11,23,25H,12H2,1-3H3,(H,22,24);2*1H |
| InChIKey | UDVALKJFXQVZSI-UHFFFAOYSA-N |
| SMILES | CC(C)(C)NCC1=C(C=C(C=C1)NC2=C3C=CC(=CC3=NC=C2)Cl)O.Cl.Cl |
| Reference | </br>1: O/’Neill PM, Shone AE, Stanford D, Nixon G, Asadollahy E, Park BK, Maggs JL, Roberts P, Stocks PA, Biagini G, Bray PG, Davies J, Berry N, Hall C, Rimmer K, Winstanley PA, Hindley S, Bambal RB, Davis CB, Bates M, Gresham SL, Brigandi RA, Gomez-de-Las-Heras FM, Gargallo DV, Parapini S, Vivas L, Lander H, Taramelli D, Ward SA. Synthesis, antimalarial activity, and preclinical pharmacology of a novel series of 4/’-fluoro and 4/’-chloro analogues of amodiaquine. Identification of a suitable /back-up/ compound for N-tert-butyl isoquine. J Med Chem. 2009 Apr 9;52(7):1828-44. doi: 10.1021/jm8012757. PubMed PMID: 19284751. |
