For research use only. Not for therapeutic Use.
GSK481(CAT: I002085) is an inhibitor of receptor-interacting serine/threonine protein kinase 1 (RIP1 or RIPK1) that blocks autophosphorylation of Ser166 on wild-type human RIP1 with an IC50 value of 2.8 nM. It is selective for RIP1 over a panel of over 450 other kinases, including RIP3. GSK481 inhibits RIP1 from humans and cynomolgus monkeys but is at least 100-fold less potent against non-primate RIP1.
| Catalog Number | I002085 |
| CAS Number | 1622849-58-4 |
| Synonyms | GSK481; GSK 481; GSK-481; (S)-5-benzyl-N-(5-methyl-4-oxo-2,3,4,5-tetrahydrobenzo[b][1,4]oxazepin-3-yl)isoxazole-3-carboxamide |
| Molecular Formula | C21H19N3O4 |
| Purity | ≥95% |
| Target | RIP kinase |
| Solubility | DMSO ≥ 35 mg/mL |
| Storage | Store at -20°C |
| IUPAC Name | 5-benzyl-N-[(3S)-5-methyl-4-oxo-2,3-dihydro-1,5-benzoxazepin-3-yl]-1,2-oxazole-3-carboxamide |
| InChI | InChI=1S/C21H19N3O4/c1-24-18-9-5-6-10-19(18)27-13-17(21(24)26)22-20(25)16-12-15(28-23-16)11-14-7-3-2-4-8-14/h2-10,12,17H,11,13H2,1H3,(H,22,25)/t17-/m0/s1 |
| InChIKey | KNOUWGGQMADIBV-KRWDZBQOSA-N |
| SMILES | O=C(C1=NOC(CC2=CC=CC=C2)=C1)N[C@@H](COC(C=CC=C3)=C3N4C)C4=OO=C(C1=NOC(CC2=CC=CC=C2)=C1)N[C@@H](COC(C=CC=C3)=C3N4C)C4=O |
