For research use only. Not for therapeutic Use.
Potent and selective Polo-like kinase (PLK) 1 inhibitor, more selective at PLK1 (IC50: 2 nM) over PLK3 (IC50: 630 nM).
KEYWORDS: GSK579289A | supplier | PLK1 inhibitor | GSK461364 analogue I | GSK 461364 analogue I | GSK-461364 analogue I | GSK 579289A | GSK-579289A | CAS [929095-23-8] | Non Selective (CHK2; p53) | PLK | Inhibitor | Enzymes
| Catalog Number | I007116 |
| CAS Number | 929095-23-8 |
| Molecular Formula | C26H27ClN4O3S |
| Purity | ≥95% |
| IUPAC Name | 3-[(1R)-1-(2-chlorophenyl)ethoxy]-5-[6-(1-methylpiperidin-4-yl)oxybenzimidazol-1-yl]thiophene-2-carboxamide |
| InChI | InChI=1S/C26H27ClN4O3S/c1-16(19-5-3-4-6-20(19)27)33-23-14-24(35-25(23)26(28)32)31-15-29-21-8-7-18(13-22(21)31)34-17-9-11-30(2)12-10-17/h3-8,13-17H,9-12H2,1-2H3,(H2,28,32)/t16-/m1/s1 |
| SMILES | C[C@H](C1=CC=CC=C1Cl)OC2=C(SC(=C2)N3C=NC4=C3C=C(C=C4)OC5CCN(CC5)C)C(=O)N |
| Reference | TR Rheault et al. Heteroaryl-linked 5-(1H-benzimidazol-1-yl)-2-thiophene carboxamides: potent inhibitors of polo-like kinase 1 (PLK1) with improved drug-like properties. Bioorg. Med. Chem. Lett. 2010, 20(15), 4587-92.
KA Emmitte et al. Design of potent thiophene inhibitors of polo-like kinase 1 with improved solubility and reduced protein binding. Bioorg. Med. Chem. Lett. 2009, 19(6), 1694-7. |
