For research use only. Not for therapeutic Use.
(-)-GSK598809(CAT: I019139) is a highly selective and potent dopamine D3 receptor antagonist, designed to modulate dopaminergic signaling without significantly affecting other dopamine receptor subtypes, particularly D2 receptors. By selectively inhibiting D3 receptors, (-)-GSK598809 is valuable in neuropharmacology research for studying addiction, reward processing, and neuropsychiatric disorders such as schizophrenia, depression, and substance use disorders. Its selective targeting of the D3 receptor offers potential therapeutic advantages in reducing drug-seeking behavior and addressing cognitive dysfunction while minimizing motor side effects commonly associated with non-selective dopamine receptor antagonists.
| CAS Number | 863680-46-0 |
| Molecular Formula | C₂₂H₂₃F₄N₅OS |
| Purity | ≥95% |
| Target | Neuronal Signaling |
| IUPAC Name | 5-[5-[3-[(1S,5R)-1-[2-fluoro-4-(trifluoromethyl)phenyl]-3-azabicyclo[3.1.0]hexan-3-yl]propylsulfanyl]-4-methyl-1,2,4-triazol-3-yl]-4-methyl-1,3-oxazole |
| InChI | InChI=1S/C22H23F4N5OS/c1-13-18(32-12-27-13)19-28-29-20(30(19)2)33-7-3-6-31-10-15-9-21(15,11-31)16-5-4-14(8-17(16)23)22(24,25)26/h4-5,8,12,15H,3,6-7,9-11H2,1-2H3/t15-,21-/m0/s1 |
| InChIKey | ZKRWPAYTJMRKLJ-BTYIYWSLSA-N |
| SMILES | CC1=C(OC=N1)C2=NN=C(N2C)SCCCN3C[C@@H]4C[C@@]4(C3)C5=C(C=C(C=C5)C(F)(F)F)F |
