For research use only. Not for therapeutic Use.
GSK621（Cat No.:I007117）is a selective inhibitor of the protein kinase PAK4, which is involved in various cellular processes, including cell growth, survival, and migration. By targeting PAK4, GSK621 disrupts oncogenic signaling pathways, making it a promising candidate for cancer research, particularly in tumors with aberrant PAK4 activity. This compound has demonstrated efficacy in preclinical studies, inhibiting tumor growth and metastasis. GSK621’s ability to modulate key signaling networks positions it as a valuable tool for exploring targeted therapies in cancers that rely on PAK4 for progression.
| Catalog Number | I007117 |
| CAS Number | 1346607-05-3 |
| Synonyms | GSK621; GSK-621; GSK 621.;6-chloro-5-(2/’-hydroxy-3/’-methoxy-[1,1/’-biphenyl]-4-yl)-3-(3-methoxyphenyl)-1,5-dihydro-2H-pyrrolo[3,2-d]pyrimidine-2,4(3H)-dione |
| Molecular Formula | C26H20ClN3O5 |
| Purity | ≥95% |
| Target | PI3K/Akt/mTOR |
| Solubility | Soluble in DMSO, not in water |
| Storage | 2-8°C |
| IUPAC Name | 6-chloro-5-[4-(2-hydroxy-3-methoxyphenyl)phenyl]-3-(3-methoxyphenyl)-1H-pyrrolo[3,2-d]pyrimidine-2,4-dione |
| InChI | InChI=1S/C26H20ClN3O5/c1-34-18-6-3-5-17(13-18)30-25(32)23-20(28-26(30)33)14-22(27)29(23)16-11-9-15(10-12-16)19-7-4-8-21(35-2)24(19)31/h3-14,31H,1-2H3,(H,28,33) |
| InChIKey | KURYSXLJGKKDHT-UHFFFAOYSA-N |
| SMILES | COC1=CC=CC(=C1)N2C(=O)C3=C(C=C(N3C4=CC=C(C=C4)C5=C(C(=CC=C5)OC)O)Cl)NC2=O |
| Reference | </br>1:Targeted activation of AMPK by GSK621 ameliorates H2O2-induced damages in osteoblasts. Liu W, Mao L, Ji F, Chen F, Hao Y, Liu G.Oncotarget. 2017 Feb 7;8(6):10543-10552. doi: 10.18632/oncotarget.14454. PMID: 28060740 Free PMC Article</br>2:GSK621 activates AMPK signaling to inhibit LPS-induced TNFα production. Wu YH, Li Q, Li P, Liu B.Biochem Biophys Res Commun. 2016 Nov 18;480(3):289-295. doi: 10.1016/j.bbrc.2016.10.001. Epub 2016 Oct 3. PMID: 27712936 </br>3:AMPK activation by GSK621 inhibits human melanoma cells in vitro and in vivo. Chen L, Chen Q, Deng G, Kuang S, Lian J, Wang M, Zhu H.Biochem Biophys Res Commun. 2016 Nov 25;480(4):515-521. doi: 10.1016/j.bbrc.2016.10.040. Epub 2016 Oct 15. PMID: 27751856 </br>4:GSK621 Targets Glioma Cells via Activating AMP-Activated Protein Kinase Signalings. Jiang H, Liu W, Zhan SK, Pan YX, Bian LG, Sun B, Sun QF, Pan SJ.PLoS One. 2016 Aug 17;11(8):e0161017. doi: 10.1371/journal.pone.0161017. eCollection 2016. PMID: 27532105 Free PMC Article |
