GSK656

• CAT Number: I020119
• CAS Number: 2131798-13-3
• Molecular Formula: C₁₀H₁₄BCl₂NO₄
• Molecular Weight: 293.94
• Purity: ≥95%
• Target: Bacterial
• IUPAC Name: 2-[[(3S)-3-(aminomethyl)-4-chloro-1-hydroxy-3H-2,1-benzoxaborol-7-yl]oxy]ethanol;hydrochloride
• InChI: InChI=1S/C10H13BClNO4.ClH/c12-6-1-2-7(16-4-3-14)10-9(6)8(5-13)17-11(10)15;/h1-2,8,14-15H,3-5,13H2;1H/t8-;/m1./s1
• InChIKey: FUOKBESTQMGROA-DDWIOCJRSA-N
• SMILES: B1(C2=C(C=CC(=C2[C@H](O1)CN)Cl)OCCO)O.Cl

GSK656（Cat No.:I020119）is a potent, selective inhibitor of the MAPK/ERK signaling pathway, specifically targeting the ERK1/2 kinases. It has shown promise in preclinical studies for its ability to modulate cell growth, survival, and differentiation in various cancer cell lines. By inhibiting ERK dimerization, GSK656 may block downstream signaling events crucial for tumor progression, offering potential therapeutic benefits in cancer treatment. Its selective mechanism of action makes it a valuable tool for understanding the role of the MAPK pathway in oncogenesis and evaluating targeted therapies in oncology research.

Reference

[1]. Li X, et al. Discovery of a Potent and Specific M. tuberculosis Leucyl-tRNA Synthetase Inhibitor: (S)-3-(Aminomethyl)-4-chloro-7-(2-hydroxyethoxy)benzo[c][1,2]oxaborol-1(3H)-ol (GSK656). J Med Chem. 2017 Oct 12;60(19):8011-8026.