For research use only. Not for therapeutic Use.
GSK8573 is an inactive control compound for GSK2801 (acetyl-lysine competitive inhibitor of BAZ2A and BAZ2B bromodomains). GSK8573 has binding activity to BRD9 with a Kd value of 1.04 μM and is inactive against BAZ2A/B and other bromodomain familiy. GSK8573 can be used as a structurally related negative control compound in biological experiments[1].
GSK8573 (1.0 μM) has binding activity to BRD9 with a Kd value of 1.04 μM and is inactive against BAZ2A/B and other bromodomain family[1].
| Catalog Number | I006835 |
| CAS Number | 1693766-04-9 |
| Synonyms | 1-[1-(3-methoxyphenyl)-7-propoxyindolizin-3-yl]ethanone |
| Molecular Formula | C20H21NO3 |
| Purity | ≥95% |
| InChI | InChI=1S/C20H21NO3/c1-4-10-24-17-8-9-21-19(14(2)22)13-18(20(21)12-17)15-6-5-7-16(11-15)23-3/h5-9,11-13H,4,10H2,1-3H3 |
| InChIKey | QQBGNWWJANJWNY-UHFFFAOYSA-N |
| SMILES | CCCOC1=CC2=C(C=C(N2C=C1)C(=O)C)C3=CC(=CC=C3)OC |
| Reference | [1]. Chen P, et al. Discovery and Characterization of GSK2801, a Selective Chemical Probe for the Bromodomains BAZ2A and BAZ2B. J Med Chem. 2016 Feb 25;59(4):1410-24. |
