For research use only. Not for therapeutic Use.
GSK8612 (CAT: I019226) is a highly selective and potent inhibitor of Tank-binding Kinase-1 (TBK1). With a pIC50 value of 6.8 for recombinant TBK1, GSK8612 demonstrates its ability to effectively inhibit the kinase activity of TBK1, an enzyme involved in various signaling pathways, including those related to inflammation, immunity, and cell survival. This inhibitor’s selectivity and potency make it a valuable tool for studying the biological roles of TBK1 and exploring its potential as a therapeutic target in diseases where TBK1 signaling is implicated.
| Catalog Number | I019226 |
| CAS Number | 2361659-62-1 |
| Molecular Formula | C₁₇H₁₇BrF₃N₇O₂S |
| Purity | ≥95% |
| Target | IKK |
| Reference | [1]. Thomson DW, et al. Discovery of GSK8612, a Highly Selective and Potent TBK1 Inhibitor. ACS Med Chem Lett. 2019 Mar 11;10(5):780-785. |
