For research use only. Not for therapeutic Use.
GSK983 is a potent broad-spectrum antiviral. It blocks cell proliferation and dengue virus replication by inhibiting the pyrimidine biosynthesis enzyme dihydroorotate dehydrogenase (DHODH).
| Catalog Number | I011914 |
| CAS Number | 827591-02-6 |
| Synonyms | GSK983; GSK-983; GSK 983;;(R)-N-(6-Chloro-2,3,4,9-tetrahydro-1H-carbazol-1-yl)picolinamide |
| Molecular Formula | C18H16ClN3O |
| Purity | ≥95% |
| Target | EBV |
| Solubility | Soluble in DMSO |
| Storage | Store at 0-8 °C |
| IUPAC Name | N-[(1R)-6-chloro-2,3,4,9-tetrahydro-1H-carbazol-1-yl]pyridine-2-carboxamide |
| InChI | InChI=1S/C18H16ClN3O/c19-11-7-8-14-13(10-11)12-4-3-6-15(17(12)21-14)22-18(23)16-5-1-2-9-20-16/h1-2,5,7-10,15,21H,3-4,6H2,(H,22,23)/t15-/m1/s1 |
| InChIKey | WJQBOBGVBBZLJU-OAHLLOKOSA-N |
| SMILES | C1CC(C2=C(C1)C3=C(N2)C=CC(=C3)Cl)NC(=O)C4=CC=CC=N4 |
| Reference | </br>1: Deans RM, Morgens DW, Ökesli A, Pillay S, Horlbeck MA, Kampmann M, Gilbert LA, Li A, Mateo R, Smith M, Glenn JS, Carette JE, Khosla C, Bassik MC. Parallel shRNA and CRISPR-Cas9 screens enable antiviral drug target identification. Nat Chem Biol. 2016 May;12(5):361-6. doi: 10.1038/nchembio.2050. Epub 2016 Mar 28. PubMed PMID: 27018887; PubMed Central PMCID: PMC4836973.</br>2: Gudmundsson KS, Boggs SD, Sebahar PR, Richardson LD, Spaltenstein A, Golden P, Sethna PB, Brown KW, Moniri K, Harvey R, Romines KR. Tetrahydrocarbazole amides with potent activity against human papillomaviruses. Bioorg Med Chem Lett. 2009 Aug 1;19(15):4110-4. doi: 10.1016/j.bmcl.2009.06.001. Epub 2009 Jun 6. PubMed PMID: 19556128.</br>3: Harvey R, Brown K, Zhang Q, Gartland M, Walton L, Talarico C, Lawrence W, Selleseth D, Coffield N, Leary J, Moniri K, Singer S, Strum J, Gudmundsson K, Biron K, Romines KR, Sethna P. GSK983: a novel compound with broad-spectrum antiviral activity. Antiviral Res. 2009 Apr;82(1):1-11. doi: 10.1016/j.antiviral.2008.12.015. Epub 2009 Jan 31. PubMed PMID: 19187793.</br></br> |
