GSK983

• CAT Number: I011914
• CAS Number: 827591-02-6
• Molecular Formula: C18H16ClN3O
• Molecular Weight: 325.80
• Purity: ≥95%
• Synonyms: GSK983; GSK-983; GSK 983;;(R)-N-(6-Chloro-2,3,4,9-tetrahydro-1H-carbazol-1-yl)picolinamide
• Target: EBV
• Solubility: Soluble in DMSO
• Storage: Store at 0-8 °C
• IUPAC Name: N-[(1R)-6-chloro-2,3,4,9-tetrahydro-1H-carbazol-1-yl]pyridine-2-carboxamide
• InChI: InChI=1S/C18H16ClN3O/c19-11-7-8-14-13(10-11)12-4-3-6-15(17(12)21-14)22-18(23)16-5-1-2-9-20-16/h1-2,5,7-10,15,21H,3-4,6H2,(H,22,23)/t15-/m1/s1
• InChIKey: WJQBOBGVBBZLJU-OAHLLOKOSA-N
• SMILES: C1CC(C2=C(C1)C3=C(N2)C=CC(=C3)Cl)NC(=O)C4=CC=CC=N4

GSK983(CAT: I011914) is a potent broad-spectrum antiviral agent that inhibits dihydroorotate dehydrogenase (DHODH), a key enzyme in the de novo pyrimidine biosynthesis pathway. By disrupting pyrimidine production, GSK983 impedes nucleotide synthesis, thereby blocking cell proliferation and viral RNA replication. This mechanism is particularly effective against dengue virus and other RNA viruses that rely on host cell nucleotide pools for replication. GSK983 serves as a valuable tool for studying antiviral mechanisms, host-virus interactions, and the therapeutic potential of targeting metabolic pathways in viral infections. Its broad-spectrum activity highlights its promise in the development of novel antiviral strategies.