For research use only. Not for therapeutic Use.
GTP-14564 is a tyrosine kinase inhibitor targeting to internal tandem duplication (ITD) and FLT3. GTP-14564 inhibits FLT3 ligand-dependent growth in Ba/F3 leukemia cells[1].
| Catalog Number | I007132 |
| CAS Number | 34823-86-4 |
| Synonyms | 3-phenyl-1H-[1]benzofuro[3,2-c]pyrazole |
| Molecular Formula | C15H10N2O |
| Purity | ≥95% |
| InChI | InChI=1S/C15H10N2O/c1-2-6-10(7-3-1)13-15-14(17-16-13)11-8-4-5-9-12(11)18-15/h1-9H,(H,16,17) |
| InChIKey | DZQLVVLATXPWBK-UHFFFAOYSA-N |
| SMILES | C1=CC=C(C=C1)C2=NNC3=C2OC4=CC=CC=C43 |
| Reference | [1]. Murata K, et al. Selective cytotoxic mechanism of GTP-14564, a novel tyrosine kinase inhibitor in leukemia cells expressing a constitutively active Fms-like tyrosine kinase 3 (FLT3). J Biol Chem. 2003 Aug 29;278(35):32892-8. |
