For research use only. Not for therapeutic Use.
GTP-14564(CAT: I007132) is a cell-permeable, reversible, and ATP-competitive tricyclic benzofurano-indazolo compound that acts as a potent and specific inhibitor of class III receptor tyrosine kinases, including c-Fms, c-Kit, and Fms-like tyrosine kinase 3 (FLT3). It exhibits inhibitory activity against both wild-type FLT3 (wt-FLT3) and FLT3 with internal tandem duplication (ITD-FLT3) mutations, with an IC₅₀ of approximately 0.3 µM. GTP-14564 has been shown to inhibit the growth of interleukin-3-independent Ba/F3 cells expressing ITD-FLT3 at 1 µM, while a 30-fold higher concentration is required to inhibit FLT3 ligand-dependent growth of Ba/F3 cells expressing wt-FLT3. Given its mechanism of action, GTP-14564 is most relevant to Cancer Disease Research, particularly in the study of acute myeloid leukemia (AML) where FLT3 mutations are implicated in disease progression.
| CAS Number | 34823-86-4 |
| Synonyms | 3-phenyl-1H-[1]benzofuro[3,2-c]pyrazole |
| Molecular Formula | C15H10N2O |
| Purity | ≥95% |
| IUPAC Name | 3-phenyl-1H-[1]benzofuro[3,2-c]pyrazole |
| InChI | InChI=1S/C15H10N2O/c1-2-6-10(7-3-1)13-15-14(17-16-13)11-8-4-5-9-12(11)18-15/h1-9H,(H,16,17) |
| InChIKey | DZQLVVLATXPWBK-UHFFFAOYSA-N |
| SMILES | C1=CC=C(C=C1)C2=NNC3=C2OC4=CC=CC=C43 |
