For research use only. Not for therapeutic Use.
GTx-007 (S-4) is an orally active and selective nonsteroidal androgen receptor modulator (SARM) and a partial agonist, with Ki of 4 nM. GTx-007 (S-4) is identified as SARMs with potent and tissue-selective in vivo pharmacological activity[1][2].
GTx-007 (S-4) is only a partial agonist in the prostate and seminal vesicles, restoring them to 33.8 and 28.2% of intact animals, respectively[2].
GTx-007 significantly increased uterine expression of Wnt4 and Wnt7a[2].
| Catalog Number | I003460 |
| CAS Number | 401900-40-1 |
| Synonyms | (2S)-3-(4-acetamidophenoxy)-2-hydroxy-2-methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]propanamide |
| Molecular Formula | C19H18F3N3O6 |
| Purity | ≥95% |
| InChI | InChI=1S/C19H18F3N3O6/c1-11(26)23-12-3-6-14(7-4-12)31-10-18(2,28)17(27)24-13-5-8-16(25(29)30)15(9-13)19(20,21)22/h3-9,28H,10H2,1-2H3,(H,23,26)(H,24,27)/t18-/m0/s1 |
| InChIKey | YVXVTLGIDOACBJ-SFHVURJKSA-N |
| SMILES | CC(=O)NC1=CC=C(C=C1)OCC(C)(C(=O)NC2=CC(=C(C=C2)[N+](=O)[O-])C(F)(F)F)O |
| Reference | [1]. Donghua Yin, et al. Pharmacodynamics of selective androgen receptor modulators. J Pharmacol Exp Ther. 2003 Mar;304(3):1334-40. |
