Guadecitabine (SGI-110)

• CAT Number: I007134
• CAS Number: 929901-49-5
• Molecular Formula: C18H24N9O10P
• Molecular Weight: 557.41
• Purity: ≥95%
• Synonyms: SGI110; SGI-110; SGI 110; S110; Guadecitabine;(2R,3S,5R)-5-(4-amino-2-oxo-1,3,5-triazin-1(2H)-yl)-2-(hydroxymethyl)tetrahydrofuran-3-yl (((2S,3R,5R)-5-(2-amino-6-oxo-1H-purin-9(6H)-yl)-3-hydroxytetrahydrofuran-2-yl)methyl) hydrogen phosphate
• Target: DNA Methyltransferase
• Solubility: Soluble in DMSO, not in water
• Storage: Store at -20°C
• InChI: InChI=1S/C18H24N9O10P/c19-16-22-6-27(18(31)25-16)12-2-8(9(3-28)35-12)37-38(32,33)34-4-10-7(29)1-11(36-10)26-5-21-13-14(26)23-17(20)24-15(13)30/h5-12,28-29H,1-4H2,(H,32,33)(H2,19,25,31)(H3,20,23,24,30)/t7-,8+,9-,10+,11-,12-/m1/s1
• InChIKey: GUWXKKAWLCENJA-ZNSALQAWSA-N
• SMILES: O=P(OC[C@@H]1O[C@@H](N2C=NC3=C2N=C(N)NC3=O)C[C@H]1O)(O[C@@H]4[C@@H](CO)O[C@@H](N5C(N=C(N)N=C5)=O)C4)O

Guadecitabine (SGI-110) is a next-generation hypomethylating agent used in cancer therapy, particularly in the treatment of myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML). It is a dinucleotide of decitabine and deoxyguanosine, designed to resist degradation by cytidine deaminase, resulting in prolonged exposure and increased efficacy compared to decitabine alone. Guadecitabine works by inhibiting DNA methyltransferase, leading to the demethylation of DNA, reactivation of tumor suppressor genes, and induction of cancer cell apoptosis. It is currently under investigation in clinical trials for its potential to improve outcomes in hematological malignancies.